METHOD AND SYSTEM FOR IDENTIFYING TUMOR LOAD IN SAMPLE

A method and device for identifying a tumor load in a sample. A method for identifying a tumor load in a sample in a non-diagnostic manner comprises the steps of: (i), providing a sample to be tested; (ii), carrying out sequencing on the sample to be tested, so as to obtain a genome sequence of the...

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Hauptverfasser: LIANG, Qinsi, LU, Sijia, REN, Jun, BO, Shiping
Format: Patent
Sprache:chi ; eng ; fre
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Zusammenfassung:A method and device for identifying a tumor load in a sample. A method for identifying a tumor load in a sample in a non-diagnostic manner comprises the steps of: (i), providing a sample to be tested; (ii), carrying out sequencing on the sample to be tested, so as to obtain a genome sequence of the sample; (iii), comparing the genome sequence obtained in the step (ii) with a reference genome, so as to obtain position information of the genome sequence on the reference genome; (iv), dividing the reference genome into M region fragments, each region fragment being a window b, and calculating the number a copies of each window b; (v), carrying out Z testing on each window b in the step (iv), so as to calculate a Z value of each window b; and (vi), calculating a genome disorder degree (GAS) according to the Z value obtained in the step (v), and identifying a tumor load in the sample to be tested according to the value of the genome disorder degree. The system and the method can improve the sensitivity and the uni