VACCINE COMPOSITIONS FOR PROTECTING AGAINST VISCERAL LEISHMANIASIS, SYNTHETIC PEPTIDES AND USES

The present technology relates to vaccine compositions for the treatment and/or prevention of visceral leishmaniasis in mammals, comprising six synthetic peptides that are free or expressed in the surface of non-infectious bacteriophages selected by means of a proteomic phase display approach for us...

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Hauptverfasser: FERRAZ COELHO, Eduardo Antônio, MENEZES SOUZA, Daniel, COSTA DUARTE, Mariana, SILVEIRA SALLES, Beatriz Cristina, EMANUELE COSTA, Lourena, MENDES ROATT, Bruno, PEREIRA TAVARES, Carlos Alberto
Format: Patent
Sprache:eng ; fre ; por
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Zusammenfassung:The present technology relates to vaccine compositions for the treatment and/or prevention of visceral leishmaniasis in mammals, comprising six synthetic peptides that are free or expressed in the surface of non-infectious bacteriophages selected by means of a proteomic phase display approach for use in isolation or in any possible combinations. La présente technologie concerne des compositions vaccinales pour le traitement et/ou la prévention de la leishmaniose viscérale chez des mammifères, comprenant six peptides synthétiques libres ou exprimés sur la surface de bactériophages non infectieux, choisis au moyen d'une approche protéomique d'exposition sur phage, en vue d'une application isolée ou en combinaisons possibles entre eux. A presente tecnologia trata de composições vacinais para o tratamento e/ou a prevenção da leishmaniose visceral em mamíferos, compreendida por seis peptídeos sintéticos livres ou expressos na superfície de bacteriofagos não infecciosos, que foram selecionados por meio de uma abordagem proteômica de phage display, para serem aplicados isoladamente ou em possíveis combinações entre os mesmos.