PYRIDINE SULFONAMIDES

The present invention provides compounds of Formula (I), as defined in the specification, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodiu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	WEISS, Matthew, SPARLING, Brian Andrew, BOEZIO, Alessandro, LA, Daniel, BUTLER, John R, MILGRAM, Benjamin Charles, RESCOURIO, Gwenaella
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides compounds of Formula (I), as defined in the specification, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention. La présente invention concerne des composés de Formule (I), tel que défini dans la spécification, ou leurs sels pharmaceutiquement acceptés, qui sont des inhibiteurs de canaux sodiques sensibles au voltage, en particulier Nav 1.7. Les composés sont utiles pour le traitement de maladies pouvant être traitées par inhibition des canaux sodiques telles que des troubles de la douleur, la toux ou les démangeaisons. L'invention concerne également des compositions pharmaceutiques contenant les composés de la présente invention.