USE OF THE COMPOUND 4-(2,3-DIHYDRO-2-THIOXO-3-BENZOXAZOLE METHYLAMINO)-SALICYLIC ACID AS AN ANTIBIOTIC

The invention relates to the use of the compound (2,3-dihydro-2-thioxo-3-benzoxazole methylamino)-salicylic acid (4-DTS) derived from 2-mercaptobenzoxazole as an antibiotic agent that specifically inhibits, in the low micromolar range, bacterial Ribonuclease P (RNase P), as well as inhibiting the gr...

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Bibliographische Detailangaben
Hauptverfasser:	MADRIGAL CARRILLO, Ezequiel Alejandro, SANTAMARÍA SUÁREZ, Hugo Aníbal, TORRES LARIOS, Alfredo
Format:	Patent
Sprache:	eng ; fre ; spa
Schlagworte:	CHEMISTRY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	The invention relates to the use of the compound (2,3-dihydro-2-thioxo-3-benzoxazole methylamino)-salicylic acid (4-DTS) derived from 2-mercaptobenzoxazole as an antibiotic agent that specifically inhibits, in the low micromolar range, bacterial Ribonuclease P (RNase P), as well as inhibiting the growth of Escherichia coli bacteria. Said 4-DTS compound can be used to produce a drug for the treatment of infectious diseases caused by gram-negative bacteria. La presente invención se refiere al uso del compuesto 4-(2,3-Dihidro-2-Tioxo-3-Benzoxazolimetilamino)-ácido salicílico (4-DTS) derivado del 2-mercaptobenzoxazol como un agente antibiótico que inhibe de manera específica y en el rango micromolar bajo a la RNasa P bacteriana e inhibe también el crecimiento de la bacteria Escherichia coli. Dicho compuesto 4-DTS es útil para preparar un medicamento para el tratamiento de enfermedades infecciosas ocasionadas por bacterias gramnegativas. La présente invention concerne l'utilisation du composé 4-(2,3-dihydro-2-tioxo-3-benzoxazoliméthylamino)-acide salicylique (4-DTS) dérivé de 2-mercaptobenzoxazole comme agent antibiotique qui inhibe de manière spécifique et au niveau micomolaire bas de la Ribonucléase P bactérienne et inhibe également la croissance de la bactérie Escherichia coli. Ce composé 4-DTS est utile pour préparer un médicament pour le traitement de maladies infectieuses causées par des bactéries à Gram négatif.