HYDROGEL PARTICLE OF CYSTAMINE CROSS-LINKED DEXTRAN ALDEHYDE CONTAINING IMINE CONJUGATED DOXORUBICIN AND RGD PEPTIDE FOR CHEMOTHERAPY

HYDROGEL PARTICLE OF CYSTAMINE CROSS-LINKED DEXTRAN ALDEHYDE CONTAINING IMINE CONJUGATED DOXORUBICIN AND RGD PEPTIDE FOR CHEMOTHERAPY

A hydrogel particle comprising: cross-linked dextran aldehyde (oxidized dextran), comprising the redox sensitive disulfide cross-linker cystamine (2,2'-disulfanediyldiethanamine), the anti-tumor agent doxorubicin conjugated to the cross-linked polymer by a pH sensitive imine bond and the cell p...

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Bibliographische Detailangaben
Hauptverfasser: OLIVA JORGE, Nuria, CONDE, Joao, ARTZI, Natalie, ZHANG, Yi
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A hydrogel particle comprising: cross-linked dextran aldehyde (oxidized dextran), comprising the redox sensitive disulfide cross-linker cystamine (2,2'-disulfanediyldiethanamine), the anti-tumor agent doxorubicin conjugated to the cross-linked polymer by a pH sensitive imine bond and the cell penetrating peptide RGD, for use in chemotherapy. L'invention concerne une particule hydrogel composée d'aldéhyde dextrane réticulé (dextrane oxydé), qui contient l'agent de réticulation à disulfure sensible à l'oxydoréduction cystamine (2,2'-disulfanediyldiéthanamine), l'agent anti-tumoral doxorubicine, conjugué au polymère réticulé par une liaison imine sensible au pH, et le peptide RGD pénétrant les cellules, s'utilisant en chimiothérapie.