METHODS OF ASSESSING AND MONITORING TUMOR LOAD

The invention disclosed herein generally relates to methods of assessing and monitoring tumor load through analysis of tumor DNA in cancer patients. Quantitative measures derived from cell-free DNA and germline DNA are used to assess and monitor tumor load. By assessing and monitoring tumor load, ca...

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Bibliographische Detailangaben
Hauptverfasser:	SPINOSA, John, C, LEVY, Samuel
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention disclosed herein generally relates to methods of assessing and monitoring tumor load through analysis of tumor DNA in cancer patients. Quantitative measures derived from cell-free DNA and germline DNA are used to assess and monitor tumor load. By assessing and monitoring tumor load, cancer may be detected in a subject. The tumor load of a subject may be assessed at a number of different time points to monitor a progression, regression, or recurrence of cancer in a subject. L'invention concerne généralement des procédés d'évaluation et de surveillance de la charge tumorale par l'analyse de l'ADN tumoral chez des patients cancéreux. Des mesures quantitatives dérivées d'ADN acellulaire et d'ADN de lignée germinale sont utilisées pour évaluer et surveiller la charge tumorale. En évaluant et en surveillant la charge tumorale, le cancer peut être détecté chez un sujet. La charge tumorale d'un sujet peut être évaluée à un certain nombre de différents points temporels pour surveiller une progression, une régression ou une récurrence de cancer chez un sujet.