TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS USING RNA COMPLEXES THAT TARGET CONNECTIVE TISSUE GROWTH FACTOR

In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit CTGF expression and are therefore useful for treating idiopathic pulmonary fibrosis. Dans certains aspects, l'invention concerne des complexes d'...

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Hauptverfasser:	KIM, Ji, NA, Yu, KIM, Young-dong, LEE, Sae-lo-oom, LEE, Dong, HONG, Sun, LEE, Tae
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Zusammenfassung:	In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit CTGF expression and are therefore useful for treating idiopathic pulmonary fibrosis. Dans certains aspects, l'invention concerne des complexes d'ARN (par exemple, des complexes d'ARN asymétriques, tels que des ARNsi ou des ARNsi de pénétration cellulaire) qui inhibent l'expression du CTGF et sont par conséquent utiles pour le traitement de la fibrose.