TERTIARY AMIDES AND METHOD OF USE

Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the comp...

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Bibliographische Detailangaben
Hauptverfasser:	PATEL, Meena, V, DEGOEY, David, A, CHEN, Da, CLAPHAM, Bruce, LI, Mingfeng, FU, Liqiang, ZHANG, Qingwei, BLACK, Lawrence, A, LANG, Qingyu, DENG, Xiangjun, TAO, Ruihong, BUNNELLE, William, H, ZHU, Wei, KONG, Linglong, ZHENG, Qiangang, LUNDGAARD, Greta, L, HAZELWOOD, Lisa, A, LEE, Chih-Hung, ZHANG, Lin
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions. L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, dans lesquels G1, G2, G3, L1, L2, et L3 sont tels que définis dans la description, qui sont utiles dans le traitement d'états ou de troubles empêchés ou améliorés par la modulation du récepteur de type 1 de l'acide lysophosphatidique. L'invention décrit des procédés de préparation de ces composés. L'invention décrit en outre des compositions pharmaceutiques des composés de formule (I), ainsi que des méthodes d'utilisation de ces composés et compositions.