METHOD TO ASSESS CHROMATOGRAPHIC COLUMN LIFE TIME

The present invention relates to the field of preparative chromatography. The invention provides a rapid method to assess the chromatographic column lifetime during a preparative scale chromatography. The method specifically measures the difference in the column back pressures obtained at two differ...

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Bibliographische Detailangaben
Hauptverfasser:	DHUNDI, Ritesh M, SRIVASTAVA, Shitanshu, SHARMA, Ketan
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CLEANING CLEANING IN GENERAL PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREVENTION OF FOULING IN GENERAL SEPARATION THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention relates to the field of preparative chromatography. The invention provides a rapid method to assess the chromatographic column lifetime during a preparative scale chromatography. The method specifically measures the difference in the column back pressures obtained at two different flow rates, during the cleaning step of a chromatographic process, to assess the re-usability or lifetime of the resin/matrix. La présente invention concerne le domaine de la chromatographie préparative. L'invention concerne un procédé rapide pour évaluer la durée de vie de colonne chromatographique pendant une chromatographie à l'échelle préparative. Le procédé mesure de manière spécifique la différence des pressions de retour de colonne obtenues à deux débits différents, pendant l'étape de nettoyage d'un processus chromatographique, afin d'évaluer la capacité de réutilisation ou la durée de vie de la résine/matrice.