METHOD FOR PRESSURE CONTROL IN CROSSFLOW FILTRATION

The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a le...

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Bibliographische Detailangaben
Hauptverfasser:	MYGAPULA, Sudheer, MAIYA, Nityananda, HEGDE, Shashidhar, MOHAN, Prashanth, Hosabettu, ARUMUGAM, Sasikumar, NUTALAPATI, Sasi, Kumar, HINDUPUR, Sameera, Simha, VERNEKAR, Ajit, S, HV, Bashkar, GEBAUER, Klaus, KARMARKAR, Nachiket
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACTUATING-FLOATS BLASTING COCKS DEVICES FOR VENTING OR AERATING ENGINEERING ELEMENTS AND UNITS GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVEFUNCTIONING OF MACHINES OR INSTALLATIONS HEATING LIGHTING MECHANICAL ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION TAPS THERMAL INSULATION IN GENERAL TRANSPORTING VALVES WEAPONS
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Beschreibung
Zusammenfassung:	The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a length of flexible tubing to a regulator valve (1; 101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer (22) adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer (39) adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer (40) adapted to measure a pressure at a permeate outlet (36) of the crossflow filter, and a control unit (23) electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP = (Pinlet + Poutlet)/2 - Pperm corresponds to a predetermined TMP value or to an interval between two predetermined TMP values, wherein Pinlet is a pressure reading from the second pressure transducer, Poutlet is a pressure reading from the first pressure transducer and Pperm is a pressure reading from the third pressure transducer. Cette invention concerne un procédé de régulation d'une pression transmembranaire (TMP) dans un appareil de filtration tangentielle, comprenant l'étape de : a) la fourniture d'un appareil de filtration tangentielle comprenant une pompe (21) raccordée de manière fluidique par l'intermédiaire d'un compartiment de rétentat (33) d'un filtre tangentiel (32) et d'une longueur de tube flexible à une vanne de régulation (1 ; 101) agissant sur le tube flexible, la vanne de régulation étant une vanne de haute précision à manchon déformable. L'appareil comprend en outre un premier transducteur de pression (22) conçu pour mesurer une pression entre le compartiment de rétentat et la vanne de régulation, un deuxième transducteur de pression (39) conçu pour mesurer une pression entre la pompe et le compartiment de rétentat, et un troisième transducteur de pression (40)