THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS

The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula (I), where R1, R2, R3, R4, R5, R5', R6, R7, X, m, and n are described herein. L'invention concerne des inhibiteurs d...

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Bibliographische Detailangaben
Hauptverfasser:	SHELEKHIN, Tatiana, MISCHKE, Steven, LI, Hongbin, SCHILLER, Shawn E. R, LANCIA JR., David R, CARAVELLA, Justin A, WANG, Zhongguo, BAIR, Kenneth W, RICHARD, David, NG, Pui Yee, GUERIN, David Joseph, IOANNIDIS, Stephanos
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula (I), where R1, R2, R3, R4, R5, R5', R6, R7, X, m, and n are described herein. L'invention concerne des inhibiteurs de l'USP28 et/ou de l'USP25 utiles dans le traitement de cancers, d'une inflammation, de maladies autoimmunes, et de maladies infectieuses, de formule (I), dans laquelle R1, R2, R3, R4, R5, R5', R6, R7, X, m, et n sont décrits dans la description.