DECELLULARISED CELL WALL STRUCTURES FROM PLANTS AND FUNGUS AND USE THEREOF AS SCAFFOLD MATERIALS

Provided herein are scaffold biomaterials comprising a decellularised plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised plant or fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for prepar...

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Bibliographische Detailangaben
Hauptverfasser:	PELLING, Andrew Edward, CUERRIER, Charles Michel, MODULEVSKY, Daniel J, HICKEY, Ryan Joseph
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Provided herein are scaffold biomaterials comprising a decellularised plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised plant or fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for preparing such scaffold biomaterials, as well as uses thereof as an implantable scaffold for supporting animal cell growth, for promoting tissue regeneration, for promoting angiogenesis, for a tissue replacement procedure, and/or as a structural implant for cosmetic surgery are also provided. Therapeutic treatment and/or cosmetic methods employing such scaffolds are additionally described. L'invention concerne des biomatériaux d'échafaudage comprenant un tissu végétal ou fongique décellularisé à partir duquel sont éliminés les matériaux cellulaires et les acides nucléiques du tissu, ledit tissu végétal ou fongique décellularisé comprenant une structure poreuse tridimensionnelle à base de cellulose ou de chitine. L'invention concerne également des procédés de préparation de tels biomatériaux d'échafaudage, ainsi que leurs utilisations comme échafaudage implantable pour supporter la croissance de cellules animales, pour favoriser la régénération tissulaire, pour favoriser l'angiogenèse, pour une procédure de remplacement des tissus, et/ou comme implant structural pour une chirurgie esthétique. L'invention concerne en outre des procédés cosmétiques et/ou de traitement thérapeutique utilisant de tels échafaudages.