METHODS AND PHARMACEUTICAL COMPOSITIONS FOR ENHANCING CD8+ T CELL-DEPENDENT IMMUNE RESPONSES IN SUBJECTS SUFFERING FROM CANCER

The present invention relates to methods and pharmaceutical compositions for enhancing CD8+ T cell-dependent immune responses in subjects suffering from cancer. In particular, the present invention relates to a method of enhancing the CD8+ T cell-dependent immune response in a subject suffering from...

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Bibliographische Detailangaben
Hauptverfasser:	SEGUI, Bruno, MEYER, Nicolas, ANDRIEU-ABADIE, Nathalie, BERTRAND, Florie, LEVADE, Thierry, ROCHOTTE, Julia, MONTFORT, Anne, COLACIOS VIATGÉ, Céline
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to methods and pharmaceutical compositions for enhancing CD8+ T cell-dependent immune responses in subjects suffering from cancer. In particular, the present invention relates to a method of enhancing the CD8+ T cell-dependent immune response in a subject suffering from cancer comprising administering to the subject a therapeutically effective amount of an agent capable of increasing intra-tumoral ceramide content. La présente invention concerne des procédés et des compositions pharmaceutiques pour amplifier des réponses immunitaires dépendantes des lymphocytes T CD8+ chez des sujets souffrant de cancer. En particulier, la présente invention concerne un procédé d'amplification de la réponse immunitaire dépendante des lymphocytes T CD8+ chez un sujet souffrant de cancer comprenant l'administration au sujet d'une quantité thérapeutiquement efficace d'un agent capable d'augmenter la teneur en céramide intratumorale.