IMPROVED PROCESS FOR THE PREPARATION OF IDELALISIB

The present invention provides an improved process for the preparation of compound of formula III by cyclizing compound of formula II in presence of hexamethyldisilazane and a base in a solvent. The compound of formula III is further converted to Idelalisib. Wherein X is an amino protecting group. L...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	JADAV, Kanaksinh Jesingbhai, PATEL, Vimeshkumar Maganlal, DWIVEDI, Shriprakash Dhar, JOSHI, Krunalkumar Chetanbhai, THENNATI, Rajamannar
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	The present invention provides an improved process for the preparation of compound of formula III by cyclizing compound of formula II in presence of hexamethyldisilazane and a base in a solvent. The compound of formula III is further converted to Idelalisib. Wherein X is an amino protecting group. La présente invention concerne un procédé amélioré pour la préparation du composé de formule III par cyclisation d'un composé de formule II en présence d'hexaméthyldisilazane et d'une base dans un solvant. Le composé de formule III est ensuite converti en idélalisib, X représentant un groupe protecteur amino.