ANGIOTENSIN II RECEPTOR ANTAGONIST METABOLITE AND NEP INHIBITOR COMPOSITE, AND PREPARATION METHOD THEREOF

Provided are a supramolecular composite comprising an angiotensin II receptor (AT1) blocking compound, a neutral endopeptidase inhibitor (NEPi), and a pharmaceutically acceptable cation. The invention further provides a method for preparing the composite and an application of the composite for prepa...

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Bibliographische Detailangaben
Hauptverfasser:	YAN, Jie, LI, Song, ZHENG, Yanxin, ZHI, Jianqiong, XU, Wenjie
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are a supramolecular composite comprising an angiotensin II receptor (AT1) blocking compound, a neutral endopeptidase inhibitor (NEPi), and a pharmaceutically acceptable cation. The invention further provides a method for preparing the composite and an application of the composite for preparing a pharmaceutical product for treating heart failure. L'invention concerne un composite supramoléculaire comprenant un composé bloquant le récepteur de l'angiotensine II (AT1), un inhibiteur de l'endopeptidase neutre (NEPi) et un cation pharmaceutiquement acceptable. L'invention concerne également un procédé permettant de préparer le composite et une application du composite pour préparer un produit pharmaceutique destiné au traitement de l'insuffisance cardiaque. 一种具有双重作用的超分子复合物，该复合物包含具有血管紧张素II受体（AT1）阻断作用的化合物、脑啡肽抑制剂（NEPi）和药学上可接受的阳离子，该复合物的制备方法以及该复合物用于制备治疗心力衰竭的药物的用途。