NANO-SENSORS FOR NUCLEIC ACID DETECTION AND DISCRIMINATION

Methods, systems, and nano-sensor devices are disclosed for detecting or discriminating nucleic acids with a single nucleotide resolution based on nucleic acid strand displacement. The detection can be made by time-lapse fluorescence measurements or by electro-based graphene FET, which can be combin...

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Bibliographische Detailangaben
Hauptverfasser:	GLINSKII, Gennadi, V, LEE, Joon, RAMACHANDRAN, Srinivasan, MO, Alexander, LAL, Ratneshwar, HWANG, Michael, Taeyoung, MECKES, Brian, LANDON, Preston, Boone
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NANOTECHNOLOGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES SPIRITS SUGARS TESTING TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Methods, systems, and nano-sensor devices are disclosed for detecting or discriminating nucleic acids with a single nucleotide resolution based on nucleic acid strand displacement. The detection can be made by time-lapse fluorescence measurements or by electro-based graphene FET, which can be combined with wireless communication to provide real-time transmission of the detected signals. Cette invention concerne des procédés, des systèmes et des dispositifs de type nano-capteurs pour détecter ou discriminer des acides nucléiques à une résolution mononucléotidique par déplacement de brin d'acide nucléique. La détection peut être mise en œuvre par des mesures de fluorescence accélérées ou par électro-FET de graphène, qui peuvent être combinées à une communication sans fil pour permettre une transmission en temps réel des signaux détectés.