METHODS FOR PREPARATION OF QUINAZOLINE DERIVATIVES

METHODS FOR PREPARATION OF QUINAZOLINE DERIVATIVES

Methods for preparing compounds having the following structure (I): (Formula (I)) or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b and R4c, are as defined herein are provided. Related compounds and methods for making the same are also...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LIU, Yuan, LI, Liansheng, SALES, Zachary S, MANI, Neelakandha S, DENG, Xiaohu, LONG, Yun Oliver, REN, Pingda, LIANG, Jimmy T, ALLISON, Brett D
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Methods for preparing compounds having the following structure (I): (Formula (I)) or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b and R4c, are as defined herein are provided. Related compounds and methods for making the same are also provided. La présente invention concerne des procédés de préparation de composés ayant la structure (I) suivante : (Formule (I)) ou un sel, un stéréoisomère, ou un tautomère pharmaceutiquement acceptables de ceux-ci, dans lesquels R1, R2a, R2b, R3a, R3b, R4a, R4b et R4c sont tels que définis dans la description. L'invention concerne également des composés et des procédés de fabrication associés.