TREATMENT OF INHIBITOR RESISTANT BRAF-MUTANT CANCERS

The disclosure relates to improved methods of treatment of cancer, in particular cancer that is resistant to treatment with MAPK pathway inhibitors, for example has acquired resistance to such MAPK pathway inhibitors. The disclosure provides pharmaceutical compositions for use in such treatment, tre...

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Bibliographische Detailangaben
Hauptverfasser:	POELL, Jos Bernard, BEIJERSBERGEN, Rodrigo Leonardus
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure relates to improved methods of treatment of cancer, in particular cancer that is resistant to treatment with MAPK pathway inhibitors, for example has acquired resistance to such MAPK pathway inhibitors. The disclosure provides pharmaceutical compositions for use in such treatment, treatment schedules using such compositions and method of treatment. The invention is based on the use of PKC activators. L'invention concerne des méthodes de traitement du cancer, notamment du cancer qui est résistant à un traitement par des inhibiteurs de la voie MAPK, par exemple ayant acquis une résistance aux dits inhibiteurs de la voie MAPK. La présente invention concerne des compositions pharmaceutiques destinées à être utilisées dans un tel traitement, des programmes thérapeutiques utilisant de telles compositions et un procédé de traitement. L'invention est basée sur l'utilisation d'activateurs de PKC.