AZOLYLACRYLOYL DERIVATIVES AS THERAPEUTIC AGENTS FOR SICKLE CELL DISEASE

Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke...

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Bibliographische Detailangaben
Hauptverfasser:	GHATGE, Mohini, OMAR, Abdelsattar, Mansour Ebid, EL-ARABY, Moustafa, El-Sayed, ABDULMALIK, Osheiza, ZHANG, Yan, SAFO, Martin, K
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING
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Beschreibung
Zusammenfassung:	Azolylacryloyl derivatives with hypoxic properties are provided. The compounds have a generic formula: and are suitable for treating sickle cell disease and hypoxia-underlying diseases, e.g. hemorrhagic and traumatic shock, cardiac arrest and cardiogenic shock, traumatic brain injury, cancer, stroke, myocardial infarction, myocardial ischemia, vaso-occlusive crisis, etc. L'invention concerne des dérivés d'azolylacryloyle avec des propriétés hypoxiques. Les composés ont une formule générale et sont appropriés pour le traitement de la drépanocytose et des maladies à la base de l'hypoxie, par exemple les chocs hémorragiques et traumatiques, les arrêts cardiaques et les chocs cardiogéniques, les lésions cérébrales traumatiques, les cancers, les attaques, les infarctus du myocarde, les ischémies myocardiques, les crises d'occlusion vasculaire, etc.