SOLID STATE FORMS OF N-[2-[(1 S)-1 -(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYL SULFONYL)ETHYL]-2,3-DIHYDRO-1,3-DIOXO-L H-ISOINDOL-4-YL]ACETAMIDE AND PROCESS FOR PREPARATION THEREOF

SOLID STATE FORMS OF N-[2-[(1 S)-1 -(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYL SULFONYL)ETHYL]-2,3-DIHYDRO-1,3-DIOXO-L H-ISOINDOL-4-YL]ACETAMIDE AND PROCESS FOR PREPARATION THEREOF

The present invention, relates to solid state forms of N-[2-[(l S)-l-(3-ethoxy-4- methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-l,3-dioxo-lH-isoindol-4-yl]acetamide represented by the following structural formula- 1 and process for their preparation. The present invention also relates to an im...

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Bibliographische Detailangaben
Hauptverfasser: PRADEEP, Rebelli, ESWARAIAH, Sajja, THIRUMALAI RAJAN, Srinivasan, VENKAT REDDY, Ghojala
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The present invention, relates to solid state forms of N-[2-[(l S)-l-(3-ethoxy-4- methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-l,3-dioxo-lH-isoindol-4-yl]acetamide represented by the following structural formula- 1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2- [(l S)-l-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-l,3-dioxo-l H- isoindol-4-yl]acetamide compound of formula- 1 and intermediates thereof. La présente invention concerne des formes à l'état solide de N-[2-[(l S)-l-(3-éthoxy-4- méthoxyphényl)-2-(méthylsulfonyl)éthyl]-2,3-dihydro-l,3-dioxo-lH-isoindol-4-yl]acétamide représenté par la formule structurelle suivante -1 et le procédé de préparation associé. La présente invention concerne également un procédé amélioré pour la préparation du composé N-[2- [(l S)-l-(3-éthoxy-4-méthoxyphényl)-2-(méthylsulfonyl)éthyl]-2,3-dihydro-l,3-dioxo-l H- isoindol-4-yl]acétamide de formule -1 et des intermédiaires de celui-ci.