CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
There is provided compounds of formula I, (I) wherein R1, R2, R3 R4, R5, R6, R7a and R7b have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipi...
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| creator | PASTOR FERNÁNDEZ, Joaquín BLANCO-APARICIO, Carmen GÓMEZ DE LA OLIVA, Cristina Ana RIESCO FAGUNDO, Rosario Concepción RIVERO BUCETA, Virginia MARTÍNEZ GONZÁLEZ, Sonia HERNÁNDEZ HIGUERAS, Ana Isabel |
| description | There is provided compounds of formula I, (I) wherein R1, R2, R3 R4, R5, R6, R7a and R7b have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. CDK8 and/or Haspin kinase) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
L'invention concerne des composés de formule I, (I) où R1, R2, R3 R4, R5, R6, R7a et R7b ont les significations indiquées dans la description, et des esters, des amides, des solvates ou des sels pharmaceutiquement acceptables de ceux-ci, lesdits composés étant utiles dans le traitement des maladies dans lesquelles une inhibition d'une protéine kinase ou d'une lipide kinase (p. ex. CDK8 et/ou kinase Haspin) est souhaitée et/ou requise et en particulier dans le traitement du cancer ou d'une maladie proliférative. |
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L'invention concerne des composés de formule I, (I) où R1, R2, R3 R4, R5, R6, R7a et R7b ont les significations indiquées dans la description, et des esters, des amides, des solvates ou des sels pharmaceutiquement acceptables de ceux-ci, lesdits composés étant utiles dans le traitement des maladies dans lesquelles une inhibition d'une protéine kinase ou d'une lipide kinase (p. ex. CDK8 et/ou kinase Haspin) est souhaitée et/ou requise et en particulier dans le traitement du cancer ou d'une maladie proliférative.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170302&DB=EPODOC&CC=WO&NR=2017033019A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170302&DB=EPODOC&CC=WO&NR=2017033019A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PASTOR FERNÁNDEZ, Joaquín</creatorcontrib><creatorcontrib>BLANCO-APARICIO, Carmen</creatorcontrib><creatorcontrib>GÓMEZ DE LA OLIVA, Cristina Ana</creatorcontrib><creatorcontrib>RIESCO FAGUNDO, Rosario Concepción</creatorcontrib><creatorcontrib>RIVERO BUCETA, Virginia</creatorcontrib><creatorcontrib>MARTÍNEZ GONZÁLEZ, Sonia</creatorcontrib><creatorcontrib>HERNÁNDEZ HIGUERAS, Ana Isabel</creatorcontrib><title>CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS</title><description>There is provided compounds of formula I, (I) wherein R1, R2, R3 R4, R5, R6, R7a and R7b have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. CDK8 and/or Haspin kinase) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
L'invention concerne des composés de formule I, (I) où R1, R2, R3 R4, R5, R6, R7a et R7b ont les significations indiquées dans la description, et des esters, des amides, des solvates ou des sels pharmaceutiquement acceptables de ceux-ci, lesdits composés étant utiles dans le traitement des maladies dans lesquelles une inhibition d'une protéine kinase ou d'une lipide kinase (p. ex. CDK8 et/ou kinase Haspin) est souhaitée et/ou requise et en particulier dans le traitement du cancer ou d'une maladie proliférative.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBy9vdzcfULdnVRCAnydI509vF0VnD29w3wD_VzCVZwDFYICPIPcfX0U_D29HMMdlXw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgaG5gbGxgaGlo6GxsSpAgByjCoh</recordid><startdate>20170302</startdate><enddate>20170302</enddate><creator>PASTOR FERNÁNDEZ, Joaquín</creator><creator>BLANCO-APARICIO, Carmen</creator><creator>GÓMEZ DE LA OLIVA, Cristina Ana</creator><creator>RIESCO FAGUNDO, Rosario Concepción</creator><creator>RIVERO BUCETA, Virginia</creator><creator>MARTÍNEZ GONZÁLEZ, Sonia</creator><creator>HERNÁNDEZ HIGUERAS, Ana Isabel</creator><scope>EVB</scope></search><sort><creationdate>20170302</creationdate><title>CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS</title><author>PASTOR FERNÁNDEZ, Joaquín ; BLANCO-APARICIO, Carmen ; GÓMEZ DE LA OLIVA, Cristina Ana ; RIESCO FAGUNDO, Rosario Concepción ; RIVERO BUCETA, Virginia ; MARTÍNEZ GONZÁLEZ, Sonia ; HERNÁNDEZ HIGUERAS, Ana Isabel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2017033019A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PASTOR FERNÁNDEZ, Joaquín</creatorcontrib><creatorcontrib>BLANCO-APARICIO, Carmen</creatorcontrib><creatorcontrib>GÓMEZ DE LA OLIVA, Cristina Ana</creatorcontrib><creatorcontrib>RIESCO FAGUNDO, Rosario Concepción</creatorcontrib><creatorcontrib>RIVERO BUCETA, Virginia</creatorcontrib><creatorcontrib>MARTÍNEZ GONZÁLEZ, Sonia</creatorcontrib><creatorcontrib>HERNÁNDEZ HIGUERAS, Ana Isabel</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PASTOR FERNÁNDEZ, Joaquín</au><au>BLANCO-APARICIO, Carmen</au><au>GÓMEZ DE LA OLIVA, Cristina Ana</au><au>RIESCO FAGUNDO, Rosario Concepción</au><au>RIVERO BUCETA, Virginia</au><au>MARTÍNEZ GONZÁLEZ, Sonia</au><au>HERNÁNDEZ HIGUERAS, Ana Isabel</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS</title><date>2017-03-02</date><risdate>2017</risdate><abstract>There is provided compounds of formula I, (I) wherein R1, R2, R3 R4, R5, R6, R7a and R7b have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. CDK8 and/or Haspin kinase) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
L'invention concerne des composés de formule I, (I) où R1, R2, R3 R4, R5, R6, R7a et R7b ont les significations indiquées dans la description, et des esters, des amides, des solvates ou des sels pharmaceutiquement acceptables de ceux-ci, lesdits composés étant utiles dans le traitement des maladies dans lesquelles une inhibition d'une protéine kinase ou d'une lipide kinase (p. ex. CDK8 et/ou kinase Haspin) est souhaitée et/ou requise et en particulier dans le traitement du cancer ou d'une maladie proliférative.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS |
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