CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS

There is provided compounds of formula I, (I) wherein R1, R2, R3 R4, R5, R6, R7a and R7b have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipi...

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Bibliographische Detailangaben
Hauptverfasser:	PASTOR FERNÁNDEZ, Joaquín, BLANCO-APARICIO, Carmen, GÓMEZ DE LA OLIVA, Cristina Ana, RIESCO FAGUNDO, Rosario Concepción, RIVERO BUCETA, Virginia, MARTÍNEZ GONZÁLEZ, Sonia, HERNÁNDEZ HIGUERAS, Ana Isabel
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	There is provided compounds of formula I, (I) wherein R1, R2, R3 R4, R5, R6, R7a and R7b have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. CDK8 and/or Haspin kinase) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. L'invention concerne des composés de formule I, (I) où R1, R2, R3 R4, R5, R6, R7a et R7b ont les significations indiquées dans la description, et des esters, des amides, des solvates ou des sels pharmaceutiquement acceptables de ceux-ci, lesdits composés étant utiles dans le traitement des maladies dans lesquelles une inhibition d'une protéine kinase ou d'une lipide kinase (p. ex. CDK8 et/ou kinase Haspin) est souhaitée et/ou requise et en particulier dans le traitement du cancer ou d'une maladie proliférative.