QUINOLONE-3-DIARYLETHERS

Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering t...

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Bibliographische Detailangaben
Hauptverfasser:	BLEYLE, Lisa, MILEY, Galen, KOOP, Dennis, NILSEN, Aaron, KELLY, Jane Xu, RISCOE, Michael, BRUZUAL, Igor, DOGGETT, J. Stone, POU, Sovitj, FORQUER, Isaac, DODEAN, Rozalia, ALDAY, Holland, LI, Yuexin, FRUEH, Lisa, STICKLES, Allison, WINTER, Rolf, SMILKSTEIN, Martin
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject. L'invention concerne des composés d'ELQ-300 comprenant un ester en position 4. Ces composés présentent des propriétés améliorées par rapport à ELQ-300. L'invention concerne également des compositions pharmaceutiques comprenant les composés et des procédés de traitement et de prévention d'infections palustres impliquant l'administration des compositions pharmaceutiques au sujet.