SOLID STATE FORMS OF TRISODIUM SALT OF VALSARTAN/SACUBITRIL COMPLEX AND SACUBITRIL
The present invention describes an amorphous form of trisodium salt of valsartan sacubitril complex and a process for the preparation of same comprising: reacting sacubitril sodium and valsartan disodium or sacubitril and valsartan in the presence of a sodium ion source in one or more solvents to ob...
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| creator | THAKER, Tirth Harikrishna SINGH, Kumar Kamlesh DIWAKAR, Santosh Devidas JADHAV, Shankar Dada VINCHHI, Kishorkumar Maneklal |
| description | The present invention describes an amorphous form of trisodium salt of valsartan sacubitril complex and a process for the preparation of same comprising: reacting sacubitril sodium and valsartan disodium or sacubitril and valsartan in the presence of a sodium ion source in one or more solvents to obtain a solution; and obtaining the trisodium salt of valsartan sacubitril complex by the removal of the solvent from the solution or by adding an anti-solvent to the solution. The crystalline form of sacubitril sodium is characterized by x-ray powder diffraction pattern having characteristic peaks expressed in terms of 2-theta at about 6.3°, 12.0°, 13.8°, 16.5°, 18.3°, 20.0° and 23.8°±0.2° (2θ).
La présente invention concerne une forme amorphe de sel trisodique d'un complexe de valsartan et sacubitril et un procédé pour la préparation de celui-ci consistant à : faire réagir sacubitril sodique et du valsartan disodique ou du sacubitril et du valsartan en présence d'une source d'ions sodium dans un ou plusieurs solvants pour obtenir une solution; et obtenir le sel trisodique d'un complexe de valsartan et de sacubitril par l'élimination du solvant de la solution ou par l'ajout d'un anti-solvant à la solution. La forme cristalline du sacubitril sodique est caractérisée par un diagramme de diffraction des rayons X sur poudre ayant des pics caractéristiques exprimés en termes de 2-thêta à environ 6,3°, 12,0°, 13,8°, 16,5°, 18,3°, 20,0° et 23,8° ± 0,2° (2θ). |
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La présente invention concerne une forme amorphe de sel trisodique d'un complexe de valsartan et sacubitril et un procédé pour la préparation de celui-ci consistant à : faire réagir sacubitril sodique et du valsartan disodique ou du sacubitril et du valsartan en présence d'une source d'ions sodium dans un ou plusieurs solvants pour obtenir une solution; et obtenir le sel trisodique d'un complexe de valsartan et de sacubitril par l'élimination du solvant de la solution ou par l'ajout d'un anti-solvant à la solution. La forme cristalline du sacubitril sodique est caractérisée par un diagramme de diffraction des rayons X sur poudre ayant des pics caractéristiques exprimés en termes de 2-thêta à environ 6,3°, 12,0°, 13,8°, 16,5°, 18,3°, 20,0° et 23,8° ± 0,2° (2θ).</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170119&DB=EPODOC&CC=WO&NR=2017009784A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170119&DB=EPODOC&CC=WO&NR=2017009784A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>THAKER, Tirth Harikrishna</creatorcontrib><creatorcontrib>SINGH, Kumar Kamlesh</creatorcontrib><creatorcontrib>DIWAKAR, Santosh Devidas</creatorcontrib><creatorcontrib>JADHAV, Shankar Dada</creatorcontrib><creatorcontrib>VINCHHI, Kishorkumar Maneklal</creatorcontrib><title>SOLID STATE FORMS OF TRISODIUM SALT OF VALSARTAN/SACUBITRIL COMPLEX AND SACUBITRIL</title><description>The present invention describes an amorphous form of trisodium salt of valsartan sacubitril complex and a process for the preparation of same comprising: reacting sacubitril sodium and valsartan disodium or sacubitril and valsartan in the presence of a sodium ion source in one or more solvents to obtain a solution; and obtaining the trisodium salt of valsartan sacubitril complex by the removal of the solvent from the solution or by adding an anti-solvent to the solution. The crystalline form of sacubitril sodium is characterized by x-ray powder diffraction pattern having characteristic peaks expressed in terms of 2-theta at about 6.3°, 12.0°, 13.8°, 16.5°, 18.3°, 20.0° and 23.8°±0.2° (2θ).
La présente invention concerne une forme amorphe de sel trisodique d'un complexe de valsartan et sacubitril et un procédé pour la préparation de celui-ci consistant à : faire réagir sacubitril sodique et du valsartan disodique ou du sacubitril et du valsartan en présence d'une source d'ions sodium dans un ou plusieurs solvants pour obtenir une solution; et obtenir le sel trisodique d'un complexe de valsartan et de sacubitril par l'élimination du solvant de la solution ou par l'ajout d'un anti-solvant à la solution. La forme cristalline du sacubitril sodique est caractérisée par un diagramme de diffraction des rayons X sur poudre ayant des pics caractéristiques exprimés en termes de 2-thêta à environ 6,3°, 12,0°, 13,8°, 16,5°, 18,3°, 20,0° et 23,8° ± 0,2° (2θ).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgK9vfxdFEIDnEMcVVw8w_yDVbwd1MICfIM9nfxDPVVCHb0CQGJhDn6BDsGhTj66Qc7Ooc6eQJV-Cg4-_sG-LhGKDj6AU2AC_MwsKYl5hSn8kJpbgZlN9cQZw_d1IL8-NTigsTk1LzUkvhwfyMDQ3MDA0tzCxNHQ2PiVAEAptowwA</recordid><startdate>20170119</startdate><enddate>20170119</enddate><creator>THAKER, Tirth Harikrishna</creator><creator>SINGH, Kumar Kamlesh</creator><creator>DIWAKAR, Santosh Devidas</creator><creator>JADHAV, Shankar Dada</creator><creator>VINCHHI, Kishorkumar Maneklal</creator><scope>EVB</scope></search><sort><creationdate>20170119</creationdate><title>SOLID STATE FORMS OF TRISODIUM SALT OF VALSARTAN/SACUBITRIL COMPLEX AND SACUBITRIL</title><author>THAKER, Tirth Harikrishna ; SINGH, Kumar Kamlesh ; DIWAKAR, Santosh Devidas ; JADHAV, Shankar Dada ; VINCHHI, Kishorkumar Maneklal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2017009784A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>THAKER, Tirth Harikrishna</creatorcontrib><creatorcontrib>SINGH, Kumar Kamlesh</creatorcontrib><creatorcontrib>DIWAKAR, Santosh Devidas</creatorcontrib><creatorcontrib>JADHAV, Shankar Dada</creatorcontrib><creatorcontrib>VINCHHI, Kishorkumar Maneklal</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>THAKER, Tirth Harikrishna</au><au>SINGH, Kumar Kamlesh</au><au>DIWAKAR, Santosh Devidas</au><au>JADHAV, Shankar Dada</au><au>VINCHHI, Kishorkumar Maneklal</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SOLID STATE FORMS OF TRISODIUM SALT OF VALSARTAN/SACUBITRIL COMPLEX AND SACUBITRIL</title><date>2017-01-19</date><risdate>2017</risdate><abstract>The present invention describes an amorphous form of trisodium salt of valsartan sacubitril complex and a process for the preparation of same comprising: reacting sacubitril sodium and valsartan disodium or sacubitril and valsartan in the presence of a sodium ion source in one or more solvents to obtain a solution; and obtaining the trisodium salt of valsartan sacubitril complex by the removal of the solvent from the solution or by adding an anti-solvent to the solution. The crystalline form of sacubitril sodium is characterized by x-ray powder diffraction pattern having characteristic peaks expressed in terms of 2-theta at about 6.3°, 12.0°, 13.8°, 16.5°, 18.3°, 20.0° and 23.8°±0.2° (2θ).
La présente invention concerne une forme amorphe de sel trisodique d'un complexe de valsartan et sacubitril et un procédé pour la préparation de celui-ci consistant à : faire réagir sacubitril sodique et du valsartan disodique ou du sacubitril et du valsartan en présence d'une source d'ions sodium dans un ou plusieurs solvants pour obtenir une solution; et obtenir le sel trisodique d'un complexe de valsartan et de sacubitril par l'élimination du solvant de la solution ou par l'ajout d'un anti-solvant à la solution. La forme cristalline du sacubitril sodique est caractérisée par un diagramme de diffraction des rayons X sur poudre ayant des pics caractéristiques exprimés en termes de 2-thêta à environ 6,3°, 12,0°, 13,8°, 16,5°, 18,3°, 20,0° et 23,8° ± 0,2° (2θ).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SOLID STATE FORMS OF TRISODIUM SALT OF VALSARTAN/SACUBITRIL COMPLEX AND SACUBITRIL |
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