METHODS, SYSTEMS AND KITS FOR CYTOTOXIC CHEMOTHERAPY-BASED PREDICTIVE ASSAYS

The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after ad...

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Bibliographische Detailangaben
Hauptverfasser:	ZIMMERMANN, Maike, HENDERSON, Paul, TURTELTAUB, Kenneth, PAN, Chong-xian, DE VERE WHITE, Ralph, William, CIMINO, George, D
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment. L'invention concerne des procédés, systèmes et nécessaires destinés à déterminer la toxicité ou l'efficacité thérapeutique de composés de traitement du cancer qui s'intègrent à l'ADN ou se lient à lui. En particulier, l'invention concerne des procédés, systèmes et nécessaires destinés à prédire le résultat de traitement d'un patient après administration d'une micro-dose d'une composition thérapeutique au patient. Les procédés fournissent aux médecins un outil de diagnostic pour séparer les patients cancéreux en populations différentielles qui ont une chance supérieure ou inférieure de répondre à un traitement thérapeutique particulier.