PREPARATION OF SACUBITRIL OR SALT THEREOF AND NOVEL INTERMEDIATES IN THE PREPARATION OF SACUBITRIL

PREPARATION OF SACUBITRIL OR SALT THEREOF AND NOVEL INTERMEDIATES IN THE PREPARATION OF SACUBITRIL

The present invention provides (4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methylbutanoic acid ethyl ester as well as method of preparing said compound. The present invention provides methods of synthesizing sacubitril involving (4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methylbutanoic acid ethyl ester a...

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Hauptverfasser: MAURYA, Sadanand Hardeo, PATIL, Ravindra Santosh, JAGTAP, Sunil Baburao, BODKHE, Arjun Rajaram, QUADRI, Syed Aziz Imam, LUTHRA, Parven Kumar, JOSHI, Ashutosh Vijay
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The present invention provides (4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methylbutanoic acid ethyl ester as well as method of preparing said compound. The present invention provides methods of synthesizing sacubitril involving (4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methylbutanoic acid ethyl ester as intermediates. La présente invention concerne un ester éthylique d'acide- (4S)-(p-phénylphénylméthyl)-4-amino-(2R) méthylbutanoïque ainsi qu'un procédé de préparation dudit composé. La présente invention concerne des procédés de synthèse de sacubitril impliquant l'ester éthylique d'acide- (4S)-(p-phénylphénylméthyl)-4-amino-(2R) méthylbutanoïque comme intermédiaire.