PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS

The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R1, R2, R3, R4, R5, R6, R7 and Ar1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides....

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Bibliographische Detailangaben
Hauptverfasser:	NATARAJAN, Vasudevan, REDDY, Dumbala Srinivasa, JACHAK, Gorakhnath Rajaram
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R1, R2, R3, R4, R5, R6, R7 and Ar1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides. La présente invention concerne un nouveau procédé monotope en deux étapes pour la synthèse d'ivacaftor et des composés associés de [formule (I)], dans laquelle R1, R2, R3, R4, R5, R6, R7 et Ar1 sont tels que décrits ci-dessus; leurs tautomères ou des sels pharmaceutiquement acceptables de ceux-ci, à partir d'amides d'acide indole acétique.