IMPROVED DISULFIDE-CONTAINING ALKYNE LINKING AGENTS

Described are improved disulfide-containing alkyne linking agents having have branched disulfides. The improved linking agents exhibit improved stability. The linking agents are useful for attachment of oligonucleotides to targeting groups or delivery agents. L'invention concerne des agents de...

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Bibliographische Detailangaben
Hauptverfasser:	ROZEMA, David, B, WAKEFIELD, Darren, H, ALMEIDA, Aaron, BENSON, Jonathan, D, BLOKHIN, Andrei, V
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	Described are improved disulfide-containing alkyne linking agents having have branched disulfides. The improved linking agents exhibit improved stability. The linking agents are useful for attachment of oligonucleotides to targeting groups or delivery agents. L'invention concerne des agents de liaison alcynes contenant du disulfure améliorés comportant des disulfures ramifiés. Les agents de liaison améliorés présentent une stabilité améliorée. Les agents de liaison sont utiles pour la fixation d'oligonucléotides à des groupes de ciblage ou agents de libération.