METHOD FOR PREPARING TICAGRELOR AND NOVEL INTERMEDIATES THEREFOR

The present invention relates to a novel method for preparing ticagrelor, (1S, 2S, 3R, 5S)-3-[7-[(1R, 2S)-2-(3,4-difluorophenyl)cyclopropylamino]-5-(propylthio)-3H-[l,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol, which is represented by the following chemical formula (...

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Bibliographische Detailangaben
Hauptverfasser:	CHA, Dae-Won, LIM, Joong In, KWAK, Woo Young, KIM, Hoo Sook, KIM, Yong Jik, SHIN, Chang Yong, KIM, Jaehan
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to a novel method for preparing ticagrelor, (1S, 2S, 3R, 5S)-3-[7-[(1R, 2S)-2-(3,4-difluorophenyl)cyclopropylamino]-5-(propylthio)-3H-[l,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol, which is represented by the following chemical formula (1), and novel intermediates used therefor. The present invention allows ticagrelor to be easily prepared from the novel intermediates: La présente invention concerne un nouveau procédé pour préparer du ticagrelor, (1S, 2S, 3R, 5S)-3-[7- [(1R, 2S)-2-(3,4-difluorophényl)-cyclopropylamino]-5-(propylthio)-3H-[l,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyéthoxy)cyclopentane-1,2-diol, qui est représenté par la formule chimique suivante (1), et de nouveaux intermédiaires utilisés à cet effet. La présente invention permet de préparer facilement du ticagrelor à partir des nouveaux intermédiaires: 본 발명의 하기 화학식 1로 표시되는 티카그렐러, (1 S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-디플루오로페닐)시클로프로필아미노] -5- (프로 필티오 )-3H-[l,2,3]트리아졸로 [4,5-d]피리미딘 -3-일] -5-(2-히드록시에톡시)시클로 펜탄 -1,2-디올의 신규한 제조방법 및 이에 사용되는 신규 중간체들에 관한 것이다. 본 발명에 따르면 티카그렐러를 신규한 중간체로부터 용이하게 제조할 수 있다: