PROCESS FOR PREPARATION OF OSPEMIFENE

PROCESS FOR PREPARATION OF OSPEMIFENE

The present invention relates to a process for the preparation of ospemifene and pharmaceutically acceptable salts thereof which comprises the step of recycling the undesired E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)phenol to generate an isomeric mixture of Z,E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)pheno...

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Bibliographische Detailangaben
Hauptverfasser: SWAMY, VEERABHADRA, KHEMNAR, EKNATH KUNDLIK, BHUSHAN, KUMAR HARI, BHIRUD, SHEKHAR BHASKAR, PATIL, DILIPKUMAR JIBHAU
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a process for the preparation of ospemifene and pharmaceutically acceptable salts thereof which comprises the step of recycling the undesired E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)phenol to generate an isomeric mixture of Z,E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)phenol. La présente invention concerne un procédé pour la préparation d'ospémifène et de sels pharmaceutiquement acceptables de celui-ci, qui comprend l'étape consistant à recycler des E-4-(4-hydroxy-1,2-diphénylbut-1-ényl)phénol indésirables pour générer un mélange isomérique de Z,E-4-(4-hydroxy-1,2-diphénylbut-1-ényl)phénol.