SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS

Disclosed are amino triazole compounds substituted by a carboxylate functional group or an bioisosteric polar functional group. Compounds having the carboxylate moiety or carboxylate bioisostere inhibit acidic mammalian chitinase. Also provided are methods of using the compounds to treat asthma reac...

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Hauptverfasser:	MATYSZEWSKI, KRZYSZTOF, OLCZAK, JACEK, CZESTKOWSKI, WOJCIECH, OLEJNICZAK, SYLWIA, GOŁĘBIOWSKI, ADAM A, KORALEWSKI, ROBERT, BECKETT, PAUL R
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are amino triazole compounds substituted by a carboxylate functional group or an bioisosteric polar functional group. Compounds having the carboxylate moiety or carboxylate bioisostere inhibit acidic mammalian chitinase. Also provided are methods of using the compounds to treat asthma reactions caused by allergens. L'invention concerne des composés de triazole aminés substitués par un groupe fonctionnel carboxylate ou un groupe fonctionnel polaire bio-isostère. Les composés ayant la fraction carboxylate ou un bio-isostère carboxylate inhibent la chitinase mammalienne acide. L'invention concerne également des procédés d'utilisation de ces composés pour traiter des réactions d'asthme provoquées par des allergènes.