VACCINE COMPOSITION

A composition for use as a vaccine to protect against Chikungunya virus (CHIKV) infection is disclosed. The composition comprises a nucleic acid comprising a nucleotide sequence encoding an attenuated poxvirus vector and one or more CHIKV structural proteins. In preferred embodiments, the nucleotide...

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Bibliographische Detailangaben
Hauptverfasser:	LILJESTRÖM, PETER, GARCÍA ARRIAZA, JUAN, RODRIGUEZ, MARIANO ESTEBAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE VINEGAR WINE
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Beschreibung
Zusammenfassung:	A composition for use as a vaccine to protect against Chikungunya virus (CHIKV) infection is disclosed. The composition comprises a nucleic acid comprising a nucleotide sequence encoding an attenuated poxvirus vector and one or more CHIKV structural proteins. In preferred embodiments, the nucleotide sequence encodes all of the C, E3, E2, 6K, and E1 structural proteins. Dosage schedules are also described. L'invention concerne une composition destinée à être utilisée comme vaccin pour protéger les sujets contre l'infection par le virus du chikungunya (CHIKV). La composition comprend un acide nucléique contenant une séquence nucléotidique codant un vecteur de poxvirus atténué et une ou plusieurs protéines structurelles de CHIKV. Dans des modes de réalisation préférés, la séquence nucléotidique code la totalité des protéines structurelles C, E3, E2, 6K et E1. L'invention concerne également des calendriers posologiques.