A NOVEL PROCESS FOR PREPARATION OF ETHYL 2-(4-HYDROXY-3-NITROPHENYL)-4-METHYL-5-THIAZOLECARBOXYLATE

A NOVEL PROCESS FOR PREPARATION OF ETHYL 2-(4-HYDROXY-3-NITROPHENYL)-4-METHYL-5-THIAZOLECARBOXYLATE

A novel process for preparation of ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate is disclosed. The process involves reaction of ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate with metal nitrate in presence of acid chloride and N,N-Dimethylformamide to produce title compo...

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Bibliographische Detailangaben
Hauptverfasser: PRABHU, MANGESH NAMDEO, SHROFF, RAVI ASHWIN, BARAI, HARISHCHANDRA LALJI, PATIL, MAHESH LAXMIKANT
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A novel process for preparation of ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate is disclosed. The process involves reaction of ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate with metal nitrate in presence of acid chloride and N,N-Dimethylformamide to produce title compound with improved yield and economics than that reported in the prior art. L'invention concerne un nouveau procédé de préparation de 2-(4-hydroxy-3-nitrophényl)-4-méthyl-5-thiazolecarboxylate d'éthyle. Le procédé implique de faire réagir du 2-(4-hydroxyphényl)-4-méthyl-5-thiazolecarboxylate d'éthyle avec un nitrate métallique en présence de chlorure d'acide et de N,N-diméthylformamide pour produire le composé selon l'invention avec un rendement amélioré et de façon plus économique que dans l'art antérieur.