SUSTAINED HIV PROTEASE INHIBITOR

Provided is a compound useful as an HIV protease inhibitor. A compound shown by formula: AA (here, ring A is BB; R4 is -Y-Z, a hydrogen atom, halogen, hydroxy, or the like; R5 is a hydrogen atom, halogen, hydroxy, or the like; R6 are each independently a halogen, hydroxy, carboxy, or the like; this R6 may bond to any bondable position on ring A; a are each independently an integer of 0-7; the ring B group is a substituted or unsubstituted aromatic carbocyclic group or a substituted or unsubstituted aromatic heterocyclic group; the ring C group is a substituted or unsubstituted aromatic carbocyclic group, substituted or unsubstituted non-aromatic carbocyclic group, substituted or unsubstituted aromatic heterocyclic group, or substituted or unsubstituted non-aromatic heterocyclic group; R1 is -Y-Z, a substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the like; R2 and R3 are each independently -Y-Z or a hydrogen atom; here, at least one of R1, R2, R3, and R4 is -Y-Z, Y is a single bond or a spacer comprising any combination selected from the group consisting of -O-, -S-, -NR7-, -C(=O)-, -SO-, -SO2-, -NR7-C(=O)-, -C(=O)-NR7-, -NR7-C(=O)-NR7-, -O-C(=O)-NR7-, -NR7-C(=O)-O-, -SO2-NR7-, -NR7-SO2-, substituted or unsubstituted alkylene, substituted or unsubstituted alkenylene, substituted or unsubstituted alkynylene, substituted or unsubstituted aromatic carbocyclic diyl, substituted or unsubstituted non-aromatic carbocyclic diyl, substituted or unsubstituted aromatic heterocyclic diyl, and substituted or unsubstituted non-aromatic heterocyclic diyl; R7 are each independently a hydrogen atom, hydroxy, carboxy, or the like; Z is a substituted aromatic carbocyclic group, substituted non-aromatic carbocyclic group, substituted aromatic heterocyclic group, or substituted non-aromatic heterocyclic group.) or a pharmaceutically acceptable salt thereof. L'invention concerne un composé utile comme inhibiteur de la protéase du VIH. L'invention concerne un composé représenté par la formule : AA (ici, le cycle A représente BB; R4 représente -Y-Z, un atome d'hydrogène, halogène, hydroxy ou analogue; R5 représente un atome d'hydrogène, halogène, hydroxy ou analogue; les radicaux R6 représentent, chacun indépendamment, halogène, hydroxy, carboxy ou analogue; R6 peut se lier à n'importe quelle position pouvant être liée sur le cycle A; les indices a représentent, chacun indépendamment, un nombre entier de 0 à 7; le c