PROCESS FOR THE PREPARATION OF APIXABAN

PROCESS FOR THE PREPARATION OF APIXABAN

The object of the invention is a process for the preparation of 1-(4-methoxyphenyl)-7-oxo-6-[4- (2-oxopiperidin- 1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide of formula 1 (apixaban), as well as the intermediates used in the process. L'invention concerne un...

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Bibliographische Detailangaben
Hauptverfasser: NAGY, TAMÁS, CSONKA-KIS, GYŐZŐ, NÉMETH, GÁBOR, MRÁVIK, ANDRÁS, FARAGÓ, JÁNOS, VOLK, BALÁZS, LUKÁCS, GYULA, SLÉGEL, PÉTER, KORMÁNY, RÓBERT, CZOBORNÉ HATVÁRI, ILONA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The object of the invention is a process for the preparation of 1-(4-methoxyphenyl)-7-oxo-6-[4- (2-oxopiperidin- 1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide of formula 1 (apixaban), as well as the intermediates used in the process. L'invention concerne un procédé de préparation d'un amide d'acide 1-(4-méthoxyphényl)-7-oxo-6- [4-(2-oxopipéridin-1-yl)phényl]-4,5,6,7-tétrahydro-1Hpyrazolo[3,4-c]pyridine-3-carboxylique de formule 1 (apixaban), ainsi que des intermédiaires utilisés dans le procédé.