PYRAZOLO-PYRIDINE DERIVATIVES AS KINASE INHIBITORS

PYRAZOLO-PYRIDINE DERIVATIVES AS KINASE INHIBITORS

A series of pyrazolo[3,4-b]pyridine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various hum...

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Bibliographische Detailangaben
Hauptverfasser: FORD, DANIEL JAMES, REUBERSON, JAMES THOMAS
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A series of pyrazolo[3,4-b]pyridine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, being selective inhibitors of phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection. L'invention concerne une série de dérivés pyrazolo[3,4-b]pyridiniques substitués en position 4 par une fraction diaza monocyclique, bicyclique pontée ou spirocyclique, qui sont des inhibiteurs sélectifs de l'activité de la phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) et sont utiles pour traiter et/ou prévenir diverses affections humaines, parmi lesquelles figurent les troubles inflammatoires, auto-immuns et oncologiques ; les maladies virales et la malaria ; ainsi que le rejet de greffes d'organes et de cellules.