IMIDAZOPYRIDAZINE DERIVATIVES AS MODULATORS OF THE GABAA RECEPTOR ACTIVITY

The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R and R6 are as defined in the description. The imidazopyri...

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Bibliographische Detailangaben
Hauptverfasser:	PRYDE, DAVID CAMERON, TAKEUCHI, MIFUNE, WATSON, CHRISTINE ANNE LOUISE, OWEN, ROBERT MCKENZIE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain. Cette invention concerne des dérivés d'imidazopyridazine. Plus particulièrement, elle concerne des dérivés de 4- (biphényl-3-yl)-7H-imidazo [4,5-c]pyridazine de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, où R1, R2, R3, R4, R et R6 sont tels que définis dans la description. Les dérivés d'imidazopyridazine selon l'invention modulent l'activité du récepteur GABAA. Ils sont utiles dans le traitement d'un certain nombre d'affections, y compris la douleur.