IMPROVED PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM II OF ROTIGOTINE

IMPROVED PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM II OF ROTIGOTINE

The present invention relates to an improved, environment friendly and cost effective process for the preparation of crystalline Form II of Rotigotine. Rotigotine, i.e. (6S)-6-{propyl[2-(2-thienyl) ethyl]amino}-5,6,7,8-tetrahydro-l-naphthalenol represented by structural formula (I), is used for the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GANGISETTY, VIJAYA KUMAR GUPTA, NEELA, PRAVEEN KUMAR, PONNAIAH, RAVI, WADEKAR, KASHYAP RAVINDRABHAI
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention relates to an improved, environment friendly and cost effective process for the preparation of crystalline Form II of Rotigotine. Rotigotine, i.e. (6S)-6-{propyl[2-(2-thienyl) ethyl]amino}-5,6,7,8-tetrahydro-l-naphthalenol represented by structural formula (I), is used for the treatment of Parkinson's disease and Willis-Ekbom disease. La présente invention a pour objet un procédé de préparation perfectionné, rentable et écologique de la forme cristalline II de la Rotigotine. La Rotigotine, à savoir le (6S)-6-{propyl[2-(2-thiényl)éthyl]amino}-5,6,7,8-tétrahydro-l-naphthalénol représenté par la formule développée (I), est utilisée pour le traitement de la maladie de Parkinson et de la maladie de Willis Ekbom.