1H-1,8- NAPHTHYRIDIN-2ONES AS ANTI PROLIFERATIVE COMPOUNDS

The present invention relates to novel antiproliferative1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In which the variable groups are as defined herein, and their preparation and use in therapeutic treatment of disorders related to inhibition o...

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Bibliographische Detailangaben
Hauptverfasser:	KOMPELLA, AMALA, SIRIGIREDDY, BALAKRISHNA REDDY, NANNAPANENI, VENKAIAH CHOWDARY, GAMPA, VENUGOPALA KRISHNA, ADIBHATLA, KALI SATYA BHUJANGA RAO, GANGANAMONI, SRINIVASULU
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel antiproliferative1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In which the variable groups are as defined herein, and their preparation and use in therapeutic treatment of disorders related to inhibition of tyrosine kinases in warm blooded animals. The compounds can overcome imatinib induced drug resistance. La présente invention concerne de nouvelles 1H-1,8-naphthyridin-2-ones antiprolifératives de formule générale (I) ou des sels pharmaceutiquement acceptables de celles-ci, dans lesquelles les groupes variables sont tels que définis dans la description, et leur préparation et leur utilisation dans le traitement thérapeutique de troubles liés à l'inhibition de tyrosine kinases chez les animaux à sang chaud. Ces composés peuvent surmonter la résistance aux médicaments induite par l'imatinib.