METHODS AND SYSTEMS FOR CONVERTING PRECURSOR CELLS INTO GASTRIC TISSUES THROUGH DIRECTED DIFFERENTIATION

Disclosed are methods of inducing formation of a gastric cells and/or a gastric tissue, such as in the form of a gastric organoid. The formation of gastric cells and/or tissue may be carried out by the activating and/or inhibiting of one or more signaling pathways within a precursor cell. Also discl...

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Hauptverfasser:	MCCRACKEN, KYLE, WILLIAM, WELLS, JAMES, MACORMACK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are methods of inducing formation of a gastric cells and/or a gastric tissue, such as in the form of a gastric organoid. The formation of gastric cells and/or tissue may be carried out by the activating and/or inhibiting of one or more signaling pathways within a precursor cell. Also disclosed are methods for using the disclosed gastric cells, gastric tissues, and/or gastric organoids derived from precursor cells. L'invention concerne des procédés d'induction de la formation d'une cellule gastrique et/ou d'un tissu gastrique, par exemple sous la forme d'un organoïde gastrique. La formation de cellules et/ou de tissu gastriques peut être obtenue par l'activation et/ou l'inhibition d'une ou plusieurs voies de signalisation dans une cellule précurseur. L'invention concerne également des procédés d'utilisation des cellules gastriques, des tissus gastriques, et/ou des organoïdes gastriques dérivés des cellules précurseurs.