METHODS FOR CHARACTERIZING AND TREATING ACUTE MYELOID LEUKEMIA

The invention features methods for characterizing and treating acute myeloid leukemia (AML) (e.g., newly diagnosed, relapsed, and refractory AML) in a subject using immunoconjugates of the invention. In one aspect, the invention generally features a method of treating acute myeloid leukemia in a sub...

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Bibliographische Detailangaben
Hauptverfasser:	NOORDHUIS, PAUL, WALKER, RUSSELL MARLIN, WHITEMAN, KATHLEEN R, LUTZ, ROBERT J, SCHUURHUIS, GERRIT JAN, KOVTUN, YELENA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention features methods for characterizing and treating acute myeloid leukemia (AML) (e.g., newly diagnosed, relapsed, and refractory AML) in a subject using immunoconjugates of the invention. In one aspect, the invention generally features a method of treating acute myeloid leukemia in a subject (e.g., a human), the method involving administering an effective amount of an immunoconjugate to a pre-selected subject, where the immunoconjugate contains a humanized or chimeric antibody or fragment conjugated to a cytotoxic benzodiazepine dimer compound via a cleavable disulfide linker. L'invention concerne des procédés permettant de caractériser et de traiter la leucémie myéloïde aiguë (LMA) (par exemple, une LMA nouvellement diagnostiquée, en récidive et réfractaire) chez un sujet au moyen des immunoconjugués de l'invention.