AZAQUINAZOLINE INHIBITORS OF ATYPICAL PROTEIN KINASE C

The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders. Compositions comprising a compound of Formula (I)...

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Bibliographische Detailangaben
Hauptverfasser:	ZULLI, ALLISON L, FOWLER, KATHERINE M, MORRIS, EMMA L, PAVE, GREGOIRE A, DUGAN, BENJAMIN J, ROFFEY, JONATHAN R.A, HUDKINS, ROBERT L, MESAROS, EUGEN F, DORSEY, BRUCE D, SOUDY, CHRISTELLE N, OLOWOYE, IKEOLUWA, MONCK, NATHANIEL JT, OTT, GREGORY R, ZIFICSAK, CRAIG A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders. Compositions comprising a compound of Formula (I) and/or a salt thereof are also provided. Cette invention concerne un composé de formule (I) et/ou un sel de celui-ci; dans la formule, R1, G, et X étant tels que définis dans la description. Un composé de formule (I) et/ou ses sels, ont une activité inhibitrice de PKC, et peuvent être utilisés pour traiter des troubles prolifératifs. L'invention porte également sur des compositions comprenant un composé de Formule (I) et/ou un sel de celui-ci.