BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AGONISTS

This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compound...

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Bibliographische Detailangaben
Hauptverfasser:	RACKHAM, MARK DAVID, TEHAN, BENJAMIN GERALD, TEOBOLD, BARRY JOHN, PICKWORTH, MARK, BROWN, GILES ALBERT, O'BRIEN, MICHAEL ALISTAIR, CONGREVE, MILES STUART, CANSFIELD, JULIE ELAINE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1 , R2, R3 and R4 are as defined herein. L'invention concerne des composés qui sont des agonistes du récepteur muscarinique M1 et qui sont utiles dans le traitement de maladies médiées par le récepteur muscarinique M1. L'invention concerne également des compositions pharmaceutiques contenant les composés et les utilisations thérapeutiques de ces composés. Les composés comprennent ceux selon la formule 1, ou un sel de celui-ci, R1 , R2, R3 et R4 étant tels que définis dans la description.