A CELLULAR DRUG SCREENING METHOD USING FACS AND LC-MS

Described herein are new methods for the rapid screening of compounds for a multiplicity of parameters in a single stage. More particularly, there is provided a novel screening method for the assessment of protein binding, cellular permeability and cytotoxicity of compounds in a single stage. L'...

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Bibliographische Detailangaben
Hauptverfasser:	MOLE, DAMIAN JAMES, WILSON, KRIS, AUER, MANFRED, WEBSTER, SCOTT PETER
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described herein are new methods for the rapid screening of compounds for a multiplicity of parameters in a single stage. More particularly, there is provided a novel screening method for the assessment of protein binding, cellular permeability and cytotoxicity of compounds in a single stage. L'invention concerne des nouveaux procédés de criblage rapide de composés à la recherche d'une multiplicité de paramètres en une seule étape. Plus particulièrement, l'invention concerne un nouveau procédé de criblage pour l'évaluation de la liaison des protéines, de la perméabilité cellulaire et de la cytotoxicité de composés en une seule étape.