ALTERNATIVE PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS

ALTERNATIVE PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS

Alternative continuous downstream processes for the production of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A") are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially...

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Bibliographische Detailangaben
Hauptverfasser: SILALAHI, SUMIHAR, ASKILDSEN, ARNE, FARBROT, ALF MARTIN, KALLEBERG, RITA, HAALAND, TORFINN, SAANUM, INGER, DAGNY
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Alternative continuous downstream processes for the production of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ("Compound A") are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents. La présente invention concerne des procédés aval continus alternatifs dans la production de 5-acétomido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophtalamide (''Composé A''). Le Composé A est un intermédiaire clé dans la production d'iodixanol et d'iohexol, qui sont deux des plus importants agents de contraste de rayons X non ioniques disponibles dans le commerce.