COMPOSITION OF A NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR

The invention encompasses a composition comprising the reverse transcriptase ("RT") inhibitor 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile sufficiently mixed in a concentration enhancing polymer...

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Bibliographische Detailangaben
Hauptverfasser:	PLOEGER, KRISTIN, J. M, LOWINGER, MICHAEL, TATAVARTI, ADITYA, S, BROOKHART, KATHERINE ANNE, MARSAC, PATRICK JULES, BLOOM, COREY, J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	The invention encompasses a composition comprising the reverse transcriptase ("RT") inhibitor 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile sufficiently mixed in a concentration enhancing polymer, and processes for making the same. The composition and processes of the present invention significantly improve the bioavailability of the aforementioned RT inhibitor, while maintaining physical stability. L'invention concerne une composition comprenant l'inhibiteur de transcriptase inverse (TI) 3-chloro-5-({1-[(4-méthyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)méthyl]-2-oxo-4-(trifluorométhyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile suffisamment mélangé à un polymère améliorant la concentration, et des procédés pour la préparer. La composition et les procédés selon la présente invention améliorent significativement la biodisponibilité de l'inhibiteur de TI susmentionné, tout en maintenant la stabilité physique.