AN IMPROVED PROCESS FOR THE PREPARATION OF DASATINIB

AN IMPROVED PROCESS FOR THE PREPARATION OF DASATINIB

The present invention relates to a novel synthetic route to N-(2-chloro-6-methylphenyl)- 2-[[6-[4-(2-hydroxyethyl)-l-piperazinyl] -2-methyl-4-pyrimidyl] amino]-5- thiazolformamide of the formula I and also relates to the process for the preparation of novel amorphous forms of dasatinib (formula I)....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PATEL, SAMIR, PARMAR, BHUPENDRA, MISTRY, SAMIR, JAYARAMAN, VENKATRAMAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a novel synthetic route to N-(2-chloro-6-methylphenyl)- 2-[[6-[4-(2-hydroxyethyl)-l-piperazinyl] -2-methyl-4-pyrimidyl] amino]-5- thiazolformamide of the formula I and also relates to the process for the preparation of novel amorphous forms of dasatinib (formula I). La présente invention concerne une nouvelle voie synthétique vers N- (2-chloro-6-méthylphényl)-2-[[6-[4-(2-hydroxyéthyl)-l-pipérazinyl]-2-méthyl-4-pyrimidyl] amino]-5-thiazolformamide de la formule I, ainsi que le procédé de préparation de nouvelles formes amorphes de dasatinib (formule I).