PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT
The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated...
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| creator | HUDSON, EDMUND C |
| description | The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT from anhydroecgonine methyl ester. The invention also relates to the alkylation of a nortropane to the corresponding N-(3-fluoropropyl) analogue using 3-fluoropropanal.
La présente invention concerne de manière générale des procédés pour la préparation de 3-fluoropropyl-nor- -CIT radio-iodé. En particulier, le procédé utilise un intermédiaire arylsilane, ce qui permet d'éviter l'utilisation d'hexaméthylditin, et de réduire le nombre d'étapes précédemment requises pour la préparation de 3-fluoropropyl-nor- -CIT radio-iodé à partir d'ester d'anhydroecgonine-méthyle. L'invention concerne également l'alkylation d'un nortropane pour l'analogue N- (3-fluoropropyl) correspondant au moyen de 3-fluoropropanal. |
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La présente invention concerne de manière générale des procédés pour la préparation de 3-fluoropropyl-nor- -CIT radio-iodé. En particulier, le procédé utilise un intermédiaire arylsilane, ce qui permet d'éviter l'utilisation d'hexaméthylditin, et de réduire le nombre d'étapes précédemment requises pour la préparation de 3-fluoropropyl-nor- -CIT radio-iodé à partir d'ester d'anhydroecgonine-méthyle. L'invention concerne également l'alkylation d'un nortropane pour l'analogue N- (3-fluoropropyl) correspondant au moyen de 3-fluoropropanal.</description><language>eng ; fre</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150402&DB=EPODOC&CC=WO&NR=2015048250A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150402&DB=EPODOC&CC=WO&NR=2015048250A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HUDSON, EDMUND C</creatorcontrib><title>PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT</title><description>The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT from anhydroecgonine methyl ester. The invention also relates to the alkylation of a nortropane to the corresponding N-(3-fluoropropyl) analogue using 3-fluoropropanal.
La présente invention concerne de manière générale des procédés pour la préparation de 3-fluoropropyl-nor- -CIT radio-iodé. En particulier, le procédé utilise un intermédiaire arylsilane, ce qui permet d'éviter l'utilisation d'hexaméthylditin, et de réduire le nombre d'étapes précédemment requises pour la préparation de 3-fluoropropyl-nor- -CIT radio-iodé à partir d'ester d'anhydroecgonine-méthyle. L'invention concerne également l'alkylation d'un nortropane pour l'analogue N- (3-fluoropropyl) correspondant au moyen de 3-fluoropropanal.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMCHINcAxyDPH091Pwd1MIcnTx9Pf0d_H0cwxxdVEw1nXzCfUP8g8AokgfXT__IF0n1xBHXWfPEB4G1rTEnOJUXijNzaDs5hri7KGbWpAfn1pckJicmpdaEh_ub2RgaGpgYmFkauBoaEycKgBFcinP</recordid><startdate>20150402</startdate><enddate>20150402</enddate><creator>HUDSON, EDMUND C</creator><scope>EVB</scope></search><sort><creationdate>20150402</creationdate><title>PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT</title><author>HUDSON, EDMUND C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2015048250A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2015</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>HUDSON, EDMUND C</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HUDSON, EDMUND C</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT</title><date>2015-04-02</date><risdate>2015</risdate><abstract>The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor- -CIT from anhydroecgonine methyl ester. The invention also relates to the alkylation of a nortropane to the corresponding N-(3-fluoropropyl) analogue using 3-fluoropropanal.
La présente invention concerne de manière générale des procédés pour la préparation de 3-fluoropropyl-nor- -CIT radio-iodé. En particulier, le procédé utilise un intermédiaire arylsilane, ce qui permet d'éviter l'utilisation d'hexaméthylditin, et de réduire le nombre d'étapes précédemment requises pour la préparation de 3-fluoropropyl-nor- -CIT radio-iodé à partir d'ester d'anhydroecgonine-méthyle. L'invention concerne également l'alkylation d'un nortropane pour l'analogue N- (3-fluoropropyl) correspondant au moyen de 3-fluoropropanal.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT |
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