NOVEL YEAST STRAINS

Sacchromyces cerevisiae strains modified to express an adhE (alcohol/aldehyde dehydrogenase) enzyme having the amino acid sequence SEQ ID NO:1, or a functional variant thereof capable of catalysing the conversion of acetyl CoA to ethanol, and/or to overexpress an ACS2 (acetyl-CoA synthetase) enzyme...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, GEORGE ROBERT, ALCASABAS, ANNETTE VICTORIA ANGELES, PARKER, DAVID ALEXANDER, ASHRAF, NADIM
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMES ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGYGENERATION, TRANSMISSION OR DISTRIBUTION SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE VINEGAR WINE
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Beschreibung
Zusammenfassung:	Sacchromyces cerevisiae strains modified to express an adhE (alcohol/aldehyde dehydrogenase) enzyme having the amino acid sequence SEQ ID NO:1, or a functional variant thereof capable of catalysing the conversion of acetyl CoA to ethanol, and/or to overexpress an ACS2 (acetyl-CoA synthetase) enzyme having the amino acid sequence SEQ ID NO:2, or a functional variant thereof capable of catalysing the conversion of acetate to acetyl CoA. Such cells have an improved ability to grow on or in acetate-containing media compared to cells not according to the invention. La présente invention concerne des souches de Saccharomyces cerevisiae modifiées pour exprimer une enzyme adhE (alcool/aldéhyde déshydrogénase) possédant la séquence d'acides aminés SEQ ID NO : 1, ou un variant fonctionnel de celle-ci capable de catalyser la conversion de l'acétyl-CoA en éthanol, et/ou de surexprimer une enzyme ACS2 (acétyl-COa synthétase) possédant la séquence d'acides aminés SEQ ID NO : 2, ou un variant fonctionnel de celle-ci capable de catalyser la conversion de l'acétate en acétyl-CoA. Lesdites cellule présentent une capacité améliorée de développement sur ou dans un milieu contenant de l'acétate par rapport à des cellules autres que celles de l'invention.