DIPHENYLOXYALKYLAMINE DERIVATIVES AND ARYLOXYALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITION, USE OF SAID PHARMACEUTICAL COMPOSITION FOR TREATING, PREVENTING OR INHIBITING CHRONIC PULMONARY INFLAMMATORY DISEASES AND METHOD FOR TREATING OR PREVENTING SUCH DISEASES

The present invention relates to diphenyloxyalkylamine derivatives and aryloxyalkylamine derivatives that are structurally analogous to mexiletine, said derivatives having important biological activity and not causing the undesired side effects observed with the prototype, as well as with other drugs from the same therapeutic class as the prototype. The derivatives of the present invention have formulas II and III and are used for treating, preventing or inhibiting pulmonary inflammatory diseases, for example, asthma and chronic obstructive pulmonary disease (COPD). La présente invention concerne des dérivés biphénoxy-alkyl-amines et aryloxy-alkyl-amines, structuralement analogues à la mexilétine, présentant d'importantes activités biologiques et dépourvus d'effets secondaires indésirables présents dans le prototype, ainsi que dans d'autres produits pharmaceutiques de la même classe thérapeutique que le prototype. Les dérivés de la présente invention possèdent les formules II et III et sont utilisés dans le traitement ou la prévention ou l'inhibition de maladies inflammatoires pulmonaires, telles que l'asthme et la broncho-pneumopathie chronique obstructive (BPCO). A presente invenção refere-se a derivados bifeniloxi-alquil-aminas e ariloxi-alquil-aminas, estruturalmente análogos à mexiletina, com importantes atividades biológicas e desprovidos dos efeitos colaterais não desejáveis presentes no protótipo, bem como em outros fármacos da mesma classe terapêutica do protótipo. Os derivados da presente invenção possuem as fórmulas II e III e são usados no tratamento ou prevenção ou inibição de doenças inflamatórias pulmonares, a exemplo da asma e doença pulmonar obstrutiva crónica (DPOC).